Zinc-Induced Seizures: A New Experimental Model of Epilepsy

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Abstract
Seizures produced by intracerebral injection of zinc sulfate in rabbits are a new chronic model of experimental epilepsy. The main features of this model are that the animals are easily controlled, the electrocorticogram is conveniently recorded, the endpoints are definite and the rate of seizure is higher than with other methods. The commonly used antiepileptic drugs, such as phenobarbital (30 mg/kg), diphenylhydantoin (30 mg/kg), nitrazepam (3 mg/kg) and sodium valproate (300 mg/kg), have therapeutic effects in treating this experimental epilepsy when given i.v., but only phenobarbital can protect the rabbits from death.