The Effect on Cell Survival of Inhalation of Oxygen under High Pressure During Irradiationin vivoof a Solid Mouse Sarcoma

Publisher Website
Google Scholar
Abstract
Solid transplanted sarcomas of CBA mice which are known to contain a high proportion of anoxic cells were irraidated in-vivo in mice breathing either oxygen at 45 lb/sq in or air at atmospheric pressure before and during irradiation. The effects of irradiation under the 2 conditions were compared in terms of the size of the fraction of reproductively intact cells surviving irradiation, as measured by in-vivo transplantation assay. In the single-dose range 2,040-3,280 R 250 kV X rays the surviving fraction after irradiation in air was greater than that in high pressure oxygen (HPO) by a factor ranging between 0.73 and 4.8. It is suggested that the enhancement of radiosensitivity indicated by these experiments would represent only a meagre therapeutic advantage in clinical terms.