CLEFT PALATE SUSCEPTIBILITY MAPS IN TWO H‐2 SUBREGIONS, H‐2K TO I‐B AND G TO H‐2D
- 1 August 1982
- journal article
- research article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 9 (4) , 243-248
- https://doi.org/10.1111/j.1744-313x.1982.tb00979.x
Abstract
The map of H-2 associated [mouse] genes which affect the glucocorticoid-induced cleft palate frequency are defined to the regions H-2K to I-B and G to H-2D. This was done by observing in 4 congenic strains the frequency of cleft palate induced by 160 mg/kg of dexamethasone administered to pregnant females on day 12 of gestation. The strains used were B10.A/SgSn, C57BL/10Sn, B10.A(5R)/SgSn and B10.A(18R)/Sg. The cleft palate frequency was observed in a large number of litters from saline-treated pregnant females. The cleft palate frequency in this control was very low and the rank of strains was the same as for the glucocorticoid-induced cleft palate frequency. The induced cleft palate frequency reflects the spontaneous occurrence of isolated cleft palate in these strains.This publication has 8 references indexed in Scilit:
- Corticosteroid-induced cleft palate in mice and H-2 haplotype: Maternal and embryonic effectsImmunogenetics, 1981
- Genetic maternal effects on cleft lip frequency in A/J and CL/Fr miceTeratology, 1980
- Genetic and Environmental Factors in Cortisone Induced Cleft PalateExperimental Biology and Medicine, 1978
- CORTISONE-INDUCED CLEFT PALATE IN THE MOUSE. A SEARCH FOR THE GENETIC CONTROL OF THE EMBRYONIC RESPONSE TRAITGenetics, 1977
- Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouseImmunogenetics, 1975
- Isolated cleft palate in A/J mice after transitory exposure to drinking‐water deprivation and low humidity in pregnancyTeratology, 1974
- Isolated cleft palate in mice after transportation during gestationTeratology, 1972
- POLYGENIC CONTROL OF THE TERATOGENICITY OF 5-FLUOROURACIL IN MICEGenetics, 1966