THE EFFECT OF CYCLOSPORIN-A ON PERIPHERAL-BLOOD T-CELL SUB-POPULATIONS IN RENAL-ALLOGRAFTS
- 1 January 1982
- journal article
- research article
- Vol. 47 (2) , 445-448
Abstract
Treatment with cyclosporin A (CyA) produces a reversal of the normal ratio of OKT4+ (inducer type) to OKT8+ (suppressor-cytotoxic type) cells so that renal allograft recipients on CyA alone develop a 4-fold increase in the absolute number of circulating OKT8 positive cells. Conventional immunosuppression with azathioprine and prednisolone reduces both populations of T cells without altering the ratio of OKT4+ to OKT8+ cells. This effect of CyA may help to explain its action as an immunosuppressive agent.This publication has 17 references indexed in Scilit:
- Effect of cyclosporin A on human lymphocyte responses in vitro. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell.The Journal of Immunology, 1981
- Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein–Barr virus-induced B-cell linesNature, 1981
- LONG-TERM T-CELL-MEDIATED IMMUNITY TO EPSTEIN-BARR VIRUS IN RENAL-ALLOGRAFT RECIPIENTS RECEIVING CYCLOSPORIN AThe Lancet, 1981
- EFFECTS OF CYCLOSPORIN A ON SUPPRESSOR AND INDUCER T LYMPHOCYTES IN PRIMARY BILIARY CIRRHOSISThe Lancet, 1980
- Regulation of the Immune Response — Inducer and Suppressor T-Lymphocyte Subsets in Human BeingsNew England Journal of Medicine, 1980
- EPSTEIN BARR VIRUS NUCLEAR ANTIGEN POSITIVE LYMPHOMA AFTER CYCLOSPORIN A TREATMENT IN PATIENT WITH RENAL ALLOGRAFTThe Lancet, 1980
- CYCLOSPORIN A IMMUNOSUPPRESSION, EPSTEIN-BARR ANTIBODY, AND LYMPHOMAThe Lancet, 1980
- CYCLOSPORIN A TO PREVENT GRAFT-VERSUS-HOST DISEASE IN MAN AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATIONThe Lancet, 1980
- CYCLOSPORIN A INITIALLY AS THE ONLY IMMUNOSUPPRESSANT IN 34 RECIPIENTS OF CADAVERIC ORGANS: 32 KIDNEYS, 2 PANCREASES, AND 2 LIVERSThe Lancet, 1979
- Selective effects of cyclosporin A on colony-forming lymphoid and myeloid cells in manNature, 1979