Regulation of the Immune Response — Inducer and Suppressor T-Lymphocyte Subsets in Human Beings

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Abstract
HUMAN T lymphocytes are endowed with the capacity to recognize specific antigens, execute effector functions, and regulate the type and intensity of virtually all cellular and humoral immune responses.1 Two major functionally distinct subsets of T cells have been defined with heteroantiserums, autoantibodies, and monoclonal antibodies directed at stable cell-surface antigens.2 3 4 5 6 7 8 Both have been independently programmed for their respective inducer (helper) and cytotoxic/suppressor functions during intrathymic differentiation. This review focuses on the biology of human regulatory T-cell subpopulations in health and disease.Development of T LymphocytesA thymic microenvironment is necessary for the differentiation of T cells in all species. . . .