Investigation of Serum Lipoprotein Metabolism in Man with I131-Labeled Triolein
- 1 January 1960
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 8 (1) , 44-49
- https://doi.org/10.1093/ajcn/8.1.44
Abstract
I131-labeled triolein was fed to subjects with normal and abnormal blood lipid patterns in order to study the role of the various serum lipoproteins in lipid transport. In all subjects labeled lipid appeared almost exclusively in the chylomicron and Sf 10–400 lipoprotein fractions. In the normal and hypercholesterolemic (elevated Sf 3–9) subjects the labeled lipid peaked early and was essentially cleared from the blood within twenty-four hours. Patients with hyperlipemia (elevated Sf 10–400) exhibited a delayed peaking of the I131-lipid level which was still considerably elevated after twenty-four hours. The results are interpreted in terms of a hypothetical scheme for lipid transport. The validity of results obtained with I131-labeled lipid is discussed.Keywords
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