GLUCOSE STUDIES IN CROCODILIA

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Abstract
Injected glucose is removed from the blood stream of the alligator at a very slow rate. This rate is detd. by the temp. of the animal and is a function of metabolic rate. Glucose space in the intact alligator is similar and may be identical in vol. with thio-cyanate space. One unit of insulin/g. body wt. produces an immediate state of "shock" which lasts a few hrs. This condition occurs during the period of hyperglycemia. A 2d state of "shock" due to hypoglycemia follows more than a day later. Large doses of insulin produce prolonged hyperglycemia. Large amts. of glucose promote the formation of liver and body glycogen. For 2 hrs. after the injn. of epinephrine no effects on blood glucose or pupillary response were observed. After 2 hrs. the pupils constrict to slits and the blood glucose rises several hundred mg. %. Epinephrine reduces the glycogen stores of the liver to about 1/3 normal and the body glycogen to about 1/2 normal in 24 hrs. Prolonged daily admn. of 10 mg. cortisone/ kg. caused a moderate hyperglycemia. Daily injns. of 5 mg. ACTH/kg. had no effect. Neither ACTH nor cortisone in the amts. listed above had any noticeable effect on electrolytes.

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