Myocardial infarction and other vascular diseases in young women. Role of estrogens and other factors

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Abstract
Women (83) younger than 46 yr with acute myocardial infarction (MI) and 154 controls were studied. There was a strong positive association between MI and the following: age, both oral contraceptive and noncontraceptive estrogen use, cigarette smoking and the presence of predisposing medical conditions, e.g., past MI, hypertension and diabetes. ABO blood type and family history of arterial disease were also positively associated with MI. The risks for idiopathic stroke and venous thromboembolism are increased among oral contraceptive users, but there is comparatively little correlation between these 2 illnesses and age or smoking in young women. The present study, together with previously published work, provides reasonable estimates of the vascular risks associated with oral contraceptive use.