Synthesis of a large peptide mimicking the DNA binding properties of the sex determining protein, SRY
- 14 September 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 309 (3) , 385-388
- https://doi.org/10.1016/0014-5793(92)80812-u
Abstract
The sex determining protein, SRY, has been recently described as containing a DNA binding motif, also called the SRY box. This 80 amino acid box was synthesized using the continuous flow solid‐phase technique. The product was then purified and tested according to such diverse criteria as its intrinsic structure or its biological activity (DNA binding capacity), and compared to the full‐length protein. The data indicate that the peptide is relevant for the properties described so far for the protein.Keywords
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