In vivo effect of the tetrapeptide, N‐Acetyl‐Ser‐Asp‐Lys‐Pro, on the G1‐S transition of rat hepatocytes
- 1 March 1990
- journal article
- research article
- Published by Wiley in Cell Proliferation
- Vol. 23 (2) , 99-103
- https://doi.org/10.1111/j.1365-2184.1990.tb01336.x
Abstract
The synthetic molecular N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), corresponding to the low molecular weight inhibitory factor preventing in vivo haematopoietic stem cell (CFU-S) entry into DNA synthesis, was tested in two heterologous systems in vivo: adult regenerating rat liver and 10-day-old rat hepatocytes synchronized by an irritating trigger. In both systems, it was shown that doses of 2-8 .mu.g kg-1 of tetrapeptide inhibited 50-70% of the hepatocyte G1-S transitions.This publication has 7 references indexed in Scilit:
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