Vagal Control of Glucagon-Induced Inhibition of Gastric Acid Secretion in Duodenal Ulcer Patients

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Abstract
To study the vagal influence on the inhibitory effect of pancreatic glucagon on gastric acid secretion, the effect of exogenous pancreatic glucagon on pentagastrin-stimulated acid secretion was studied in duodenal ulcer patients before and after parietal cell vagotomy without drainage (PCV). Preoperatively, exogenous pancreatic glucagon inhibited gastric acid secretion, whereas no effect was found postoperatively. Plasma pancreatic glucagon was identical pre- and post-operatively and was within the physiological range. The inhibitory effect of pancreatic glucagon on pentagastrin-stimulated gastric acid secretion is dependent on an intact vagal innervation of the parietal cell area.