Inhibition of Acid Secretion from Vagally Innervated and Denervated Gastric Pouches by (Gln4)-Neurotensin
- 1 March 1980
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 15 (2) , 253-256
- https://doi.org/10.3109/00365528009181465
Abstract
In dogs with innervated fundic pouches an intravenous infusion of (Gln4)-neurotensin, 60 pmol x kg-1x min-1, reduced the pentagastrin-stimulated acid secretion to 40% of the control secretory rate. After vagal denervation of the fundic pouches the same dose of (Gln4)-neurotensin did not significantly change the secretion. These findings suggest that (Gln4)-neurotensin does not act directly on parietal cells but inhibits acid secretion at a presynaptic level.Keywords
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