THYMOCYTE INVOLVEMENT IN SPLEEN COLONY FORMATION BY SUB-POPULATIONS OF HEMATOPOIETIC STEM-CELLS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 9  (10) , 1011-1019
Abstract
Murine marrow preparations depleted of stem cells by prior incubation with rabbit, anti-mouse brain serum show augmented spleen colony-forming ability when exposed to fresh thymocytes. A 2- to 4-fold increase in colonies was observed when marrow-thymocyte interaction occurred under either in vivo or in vitro conditions. Colony augmentation was independent of both the strain used and the age of the thymocyte donor. Approximately 1/2 of the marrow stem cells surviving an exposure to the antiserum appear responsive to thymocyte interaction.