Influence of Chelation on Gold Metabolism in Rats

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Abstract
The method of thermal neutron activation analysis was applied to the measurement of gold in urine, feces and tissue samples. It was possible to determine gold with a standard deviation of [plus or minus] 5% in the range of 0.05 to 40.0 [mu]g/ml. The effect on the excretion and tissue distribution of gold in combination with various organic sulfhydryl ligands was studied following intramuscular administration of rats. As in the earlier literature, intramuscular gold thioglucose was excreted in urine and feces with highest tissue deposition in kidney, spleen, liver and lung. Gold mercaptoethyliminodiacetic acid provided higher urine kidney and spleen concentrations than gold thioglucose. The administration of the gold free binding compounds to animals with pre-deposited tissue gold resulted in a variable increase in urine gold output and a redistribution of the tissue gold. Kidney gold deposition increased in this process.

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