Effect of Aminotriazole on Alcohol Metabolism and Hepatic Enzyme Activities in Several Species

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Abstract
3 Amino-l,2,4-triazole (AT), in dosages of 1 g/kg body weight injected intraperitoneally in rats, dogs, and mice, markedly reduced the hepatic catalase activity. When AT was given following ethanol injection, hepatic catalase activity was only slightly affected. The cause of the protective action of ethanol was not determined. The rate of ethanol metabolism was not significantly altered in the dog even though the hepatic catalase activity was reduced 71.8% below control values following administration of AT. Apparently hepatic catalase can not play a dominant role in the metabolism of ethanol.

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