Abnormal Calcium Homeostasis in Sarcoidosis

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Abstract
Sarcoidosis is a fascinating multifocal disorder of unknown origin,1 which first attracted the attention of endocrinologists in 1939, when Harrell and Fisher2 reported hypercalcemia as a complication in 8 of 11 cases. Since then, it has been observed that mild to severe hypercalcemia may appear, often transiently, in approximately 10 percent of patients and that hypercalciuria is considerably more common.3 In the early 1950s, the efficacy of glucocorticoids in reversing the hypercalcemia and hypercalciuria of sarcoidosis was established.4 , 5 O'Leary and colleagues remind us in this issue of the Journal that chloroquine is also effective in the management of sarcoidosis with . . .