PLASMA-RENIN SUBSTRATE AND ESTROGENS IN NORMAL-PREGNANCY

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (1) , 61-65
Abstract
Relationship between concentrations of serum estrogens, plasma renin substrate and plasma renin activity were studied in 6 women throughout pregnancy. There was a significant positive correlation between serum estradiol-17.beta. and plasma renin substrate concentrations (r = 0.60). Serum estriol concentrations also correlated significantly with plasma renin substrate concentrations (r = 0.68). Correlation coefficients calculated separately for each subject throughout pregnancy were higher than those for the whole group. Also, there was much individual variation in dose-response of serum estrogens to plasma renin substrate concentrations. There was no significant correlation between serum estrogens and plasma renin activity. The view that estrogens cause the increase in plasma renin substrate concentration during pregnancy was supported, and the individual variation in response of renin substrate concentration to serum level of estrogens was emphasized.