STUDIES ON ALCOHOL DIURESIS. III. THE RESPONSE TO ETHYL ALCOHOL IN CERTAIN DISEASE STATES CHARACTERIZED BY IMPAIRED WATER TOLERANCE 1

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Abstract
Ethyl alcohol, a known inhibitor of the release of ADH from the neurohypophysis, was given orally to 16 patients with various diseases characterized by impaired water tolerance. Eleven of 13 patients in whom impaired water tolerance was demonstrated failed to respond to ethanol with a diuresis of water. Cortisone restored the ability of one patient with Addison''s disease to respond normally with a diuresis both to water and to alcohol. Data do not support the contention that excess activity of ADH is chiefly responsible for the disturbed water tolerance characterizing the disease states studied.