STUDIES ON ALCOHOL DIURESIS. II. THE EVALUATION OF ETHYL ALCOHOL AS AN INHIBITOR OF THE NEUROHYPOPHYSIS 12
Open Access
- 1 March 1955
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 34 (3) , 448-455
- https://doi.org/10.1172/jci103093
Abstract
Alcohol had no effect upon urine flow or solute excretion when given at the height of a water diuresis. Alcohol blocked the antidiuretic response to hypertonic saline when both were simultaneously given to water-loaded subjects. Alcohol minimized the antidiuretic effect of venous congestion of the legs in water-loaded subjects, when imbibed before the legs were congested. The characteristic diuretic response to alcohol was blockedby prior infusion of hypertonic saline or cuff congestion of the limbs. When given prior to the stimulus, alcohol will effectively block stimulation of the release of ADH.Keywords
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