Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 36 (3) , 243-249
- https://doi.org/10.1007/bf00685368
Abstract
Amyloid fibrils in senile plaques of the brain of patients with senile dementia or Alzheimer's disease combined specifically with horseradish peroxidase (HRPO)-labeled rabbit anti-human IgG. Light and electron-microscopic immunoperoxidase technique was used to prove this. The fact may mean that immunological factors were involved in the pathogenesis of amyloid fibrils in the senile plaques, and probably also in that of senile dementia or Alzheimer's disease.Keywords
This publication has 11 references indexed in Scilit:
- Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody techniqueActa Neuropathologica, 1975
- PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATIONJournal of Histochemistry & Cytochemistry, 1974
- PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPYJournal of Histochemistry & Cytochemistry, 1974
- The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly SubjectsThe British Journal of Psychiatry, 1968
- Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementiaActa Neuropathologica, 1967
- ALZHEIMERS PRESENILE DEMENTIA - A HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDY1965
- Gamma-Globulin Affinity for Normal Human Tissue of the Central Nervous SystemScience, 1964
- ULTRASTRUCTURAL STUDIES IN ALZHEIMERS PRESENILE DEMENTIA1964
- ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDYBrain, 1964
- SENILE CEREBRAL DISEASE - A CRITICAL SURVEY OF TRADITIONAL CONCEPTS BASED UPON OBSERVATIONS WITH NEWER TECHNICS1959