Clinical study to compare the effect of stannous fluoride and chlorhexidine mouthrinses on plaque formation

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Abstract
A clinical study was conducted on 4 [human] adults to compare the relative efficacy of 0.2% chlorhexidine digluconate and 0.1% stannous fluoride (SnF-2). Using a crossover experimental design, subjects rinsed twice daily for 5 days with SnF2 and then, after a 2 day interim recovery period, for 5 days with chlorhexidine. Statistically significant differences (P < 0.05) in the relative efficacy of the 2 agents were found. Chlorhexidine was more effective in reducing gingival and plaque indices, plaque wet weight and bacterial colony forming units, calculated per subject and per group.