Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures.
- 1 January 1989
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 42 (10) , 1475-1481
- https://doi.org/10.7164/antibiotics.42.1475
Abstract
The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3,10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.This publication has 4 references indexed in Scilit:
- Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.The Journal of Antibiotics, 1989
- Secondary mould metabolites. Part 13. Fungal perylenequinones: phleichrome, isophleichrome, and their endoperoxidesJournal of the Chemical Society, Perkin Transactions 1, 1985
- Stereochemistry of cercosporinTetrahedron, 1982
- Phleichrome; A New Phytotoxic Compound Produced byCladosporium phleiAgricultural and Biological Chemistry, 1975