Studies in the biochemistry of micro-organisms

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Abstract
Griseofulvin, C17H17O6Cl, M.P. 218-219[degree], a hitherto undescribed ketonic mould metabolic product, was isolated from the mycelium of Penicillium griseo-fulvum grown on a modified Czapek-Dox solution. The general properties of griseofulvin are descr. together with a number of derivatives (including the dihydro-derivative) and degradation products (including orcinol (by KOH fusion) and 3-chloro-2-hydroxy-4.6-dimethoxybenzoic acid (by KMnO4 oxidation)). A provisional structural formula is assigned.

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