cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase
Open Access
- 20 May 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 283 (1) , 122-126
- https://doi.org/10.1016/0014-5793(91)80568-n
Abstract
The β‐adrenergic receptor kinase (βARK) mediates agonist‐dependent phosphorylation of the β2‐adrenergic and related G protein‐coupled receptors. A cDNA encoding bovine βARK has recently been isolated. In this work we have isolated a cDNA encoding human βARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity with bovine βARK. Chromosomal location of the human βARK gene was determined by correlating the presence of the βARK locus with retention of a specific human chromosome in a rodent‐human hybrid panel. This analysis revealed that the human βARK locus segregated with the long arm of chromosome 11, centromeric to 11q13.Keywords
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