Large-Scale Surveillance of Plasmodium falciparum crt ( K76T ) in Northern Ghana
- 1 September 2007
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (9) , 3407-3409
- https://doi.org/10.1128/aac.00179-07
Abstract
Surveillance of Plasmodium falciparum crt ( K76T ) [Pf crt ( K76T )], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pf crt ( K76T ) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.Keywords
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