A Single Nucleotide Substitution in the Transcription Start Signal of the M2 Gene of Respiratory Syncytial Virus Vaccine Candidatecpts248/404 Is the Major Determinant of the Temperature-Sensitive and Attenuation Phenotypes

This publication has 29 references indexed in Scilit:

• A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees
  Vaccine, 1994
• Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis
  Vaccine, 1994
• A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV
  Vaccine, 1993
• Respiratory syncytial virus puzzle: Clinical features, pathophysiology, treatment, and prevention
  The Journal of Pediatrics, 1992
• An Outbreak of Respiratory Syncytial Virus in a Bone Marrow Transplant Center
  The Journal of Infectious Diseases, 1992
• Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys
  Virus Research, 1992
• Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3–6 months after immunization
  Vaccine, 1990
• At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells
  Journal of Molecular Biology, 1987
• Respiratory Syncytial Viral Infection in Children with Compromised Immune Function
  New England Journal of Medicine, 1986
• Low-temperature-grown RS virus in adult volunteers
  Published by American Medical Association (AMA) ,1968