Transfer of Salbutamol in the Human Placenta in vitro

Publisher Website
Google Scholar
Abstract
The maternal-fetal transfer of salbutamol [a .beta.2-agonist] was studied in vitro, in dual perfusion of isolated human placental lobules. The fraction of drug transferred to the fetal side was compared to reference substances: (14C)-antipyrine and (3H)-inulin. Salbutamol transfer (12%) represents .apprx. 39% of antipyrine and 5 times of inulin transfer. Studies with varying salbutamol concentrations in the maternal arterial perfusate revealed that the drug transfer to the fetal side was effected by a flow-dependent diffusion process. The reported effects on the fetus following a maternal drug infusion are mediated by the drug transferred across the placenta.