Effect of Candesartan and Verapamil on Exercise Tolerance in Diastolic Dysfunction
- 1 February 2004
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 43 (2) , 288-293
- https://doi.org/10.1097/00005344-200402000-00019
Abstract
Diastolic dysfunction may be exacerbated by increased systolic blood pressure (SBP) during exercise. Ang II may contribute to this process. We performed a randomized, double-blind, crossover study of two weeks of candesartan (16 mg) and verapamil (SR 160 mg). The 21 subjects were 64 ± 10 years old with ejection fraction greater than 50%, no ischemia, mitral flow velocity E/A less than 1, normal resting SBP (PKeywords
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