Chicamycin, a new antitumor antibiotic. II. Structure determination of chicamycins A and B.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (3) , 200-206
- https://doi.org/10.7164/antibiotics.37.200
Abstract
Structures of chicamycins A and B were determined from a series of chemical degradation studies coupled with spectroscopic analysis. Chicamycin A is 2(S),11(R),11a(S)-1,2,3,10,11,11a-hexahydro-2,8-dihydroxy-7,11-dimethoxy-5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-5-one. Chicamycin B is 2(S),11a(S)-1,2,3,11a-tetrahydro-2,8-dihydroxy-7-methoxy-5H-pyrrolo-[2,1-c][1,4]-benzodiazepin-5-one, which is the demethanol form of chicamycin A. The structure of chicamycin B is closely related to that of neothramycin, differing only in the position of a hydroxyl substituent on the pyrrolidine ring.This publication has 4 references indexed in Scilit:
- Chicamycin, a new antitumor antibiotic. I. Production, isolation and properties.The Journal of Antibiotics, 1984
- Prothracarcin, a novel antitumor antibiotic.The Journal of Antibiotics, 1982
- Structure and synthesis of neothramycin.The Journal of Antibiotics, 1977
- Neothramycins A and B, new antitumor antibiotics.The Journal of Antibiotics, 1976