Vascular permeability changes in the central nervous system of rats with hyperacute experimental allergic encephalomyelitis induced with the aid of a substance from Bordetella pertussis

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Abstract
Development of hyperacute experimental allergic encephalomyelitis in Lewis rats after i.p. administration of a mixture of guinea pig spinal cord emulsion and pertussigen from B. pertussis was accompanied by an increase in vascular permeability in the CNS. The increased permeability was most striking in the spinal cord and seemed to be associated with the ascending development of paralysis. Rats that completely recovered from paralysis did not have any increased permeability in the CNS. Rats which developed paralysis after inoculation with guinea pig spinal cord emulsion alone or with complete Freund adjuvant had only a small degree, if any, of increased permeability in the vascular system of the CNS.