Effect of X-Irradiation on Gastric Secretion and the Accompanying Gross and Histological Changes in the ‘Shay’ Rat Stomach

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Abstract
The ulcerative changes and the peptic-HCl activity occurring in the "Shay" rat preparation were confirmed. Prior-irradiation of rats subjected to pyloric ligation resulted in a great variation in response. Pepsin-HCl activity was or was not decreased, but when the former occurred the usual lytic ulcerative lesions developed in the stomach rumen; the body was only slightly changed and the antrum was essentially unaffected. When there was a decrease in the pepsin-HCl activity, the resulting lesions were comparable to changes resulting from irradiation alone. Irradiation alone reduced the lytic effect on the epithelium of the rumen, but the accompanying vascular effect was equally as severe as that seen in the "Shay" rat. In both the irradiated and the irradiated-ligated rats, lesions in the stomach body were characterized by single terminal vascular tuft engorgements that coalesced into focal engorged vascular networks with or without hemorrhagic ulcerations. Such lesions were absent in the "Shay" rat preparation.