De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation
- 29 April 2007
- journal article
- Published by Elsevier in Free Radical Biology & Medicine
- Vol. 43 (3) , 444-453
- https://doi.org/10.1016/j.freeradbiomed.2007.04.016
Abstract
No abstract availableKeywords
This publication has 46 references indexed in Scilit:
- Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cellsRedox Report, 2007
- The antifibrogenic effect of (−)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cellsLaboratory Investigation, 2006
- Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factorAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2006
- Activation of PPARγ is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitroBiochemical Journal, 2004
- Curcumin alters EpRE and AP‐1 binding complexes and elevates glutamate‐cysteine ligase gene expressionThe FASEB Journal, 2003
- Liver fibrosis – from bench to bedsideJournal of Hepatology, 2003
- The antioxidant (−)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expressionBiochemical Journal, 2002
- An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit GeneJournal of Biological Chemistry, 1998
- Drug Antioxidant EffectsDrugs, 1991
- The Biology of Oxygen RadicalsScience, 1978