Inositol trisphosphate accumulation by high K+ stimulation in cultured adrenal chromaffin cells
Open Access
- 2 November 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 223 (2) , 413-416
- https://doi.org/10.1016/0014-5793(87)80330-7
Abstract
Stimulation with high K+ (KCl, 56 mM) of myo‐[3H]inositol‐prelabelled cells increased Ca2+ uptake and [3H]inositol trisphosphate (IP3) accumulation in a concentration‐dependent manner. Nifedipine, a Ca2+ channel antagonist, inhibited high K+‐induced [3H]IP3 accumulation and 45Ca2+ uptake with a similar potency. Furthermore, ionomycin (1 μM), a Ca2+ ionophore, also induced 45Ca2+ uptake and [3H]IP3 accumulation. These results indicate the existence of the Ca2+ uptake‐triggered mechanism of IP3 formation in cultured adrenal chromaffin cells.Keywords
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