THE EFFECT OF GLUCOSE ON THE ADRENAL RESPONSE TO ACTH IN HYPOPHYSECTOMIZED RATS

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Abstract
It was found that in hypophysectomized rats both Armour''s and Li''s ACTH increased the glycogen formation from glucose in the liver, while neither ACTH caused any glycogen formation when given alone up to 6 hrs. after injn. Neither Armour''s nor Li''s ACTH had any significant effect on the blood sugar when given alone, but Armour''s ACTH increased the alimentary hyperglycemia produced by oral glucose admn. Armour''s ACTH produced a slight adrenal cholesterol discharge, which was considerably augmented by the addition of glucose. Glucose alone did not affect the adrenal cholesterol concn. At the dosage level used, Li''s ACTH produced a maximal adrenal cholesterol discharge which was not influenced by glucose. Armour''s ACTH had only a slight and transitory action on the lymphatic tissues when given alone. The addition of glucose considerably augmented and prolonged this effect. Glucose alone did not affect the lymphatic organs. Glucose accelerated the adrenal ascorbic acid repletion following injn. of either Armour''s or Li''s ACTH. Glucose alone had no significant effect on the adrenal ascorbic acid concn. It is concluded that the admn. of glucose augments the adrenal response to ACTH.