THE CELLULAR CONTENT OF DERMAL LEPROUS GRANULOMAS - AN IMMUNO-HISTOLOGICAL APPROACH
- 1 January 1984
- journal article
- research article
- Vol. 52 (3) , 318-326
Abstract
An indirect immunofluorescence technique with monoclonal antibodies was used to identify T cells, T helper cells, T suppressor cells and granulocytes in the dermal granulomas of 22 patients with leprosy. In tuberculoid leprosy, T helper cells predominated and T suppressor cells were located at the periphery of well-circumscribed granulomas. In lepromatous leprosy, the 2 subsets of T cells were numerous in treated patients. In erythema nodosum leprosum lesions, T cells were more numerous and T helper cells predominated. Enumerations of the T cell subsets in the dermis and in the blood showed similar changes, but these changes were quantitatively more marked in the dermal granulomas.This publication has 12 references indexed in Scilit:
- INSITU DEMONSTRATION OF LYMPHOCYTE-T SUBSETS IN GRANULOMATOUS INFLAMMATION - LEPROSY, RHINOSCLEROMA AND SARCOIDOSIS1983
- T-CELL SUBSETS IN LEPROSY LESIONS - INSITU CHARACTERIZATION USING MONOCLONAL-ANTIBODIES1983
- Serum Macrophage Migration Inhibition Activity in Patients with LeprosyJournal of Investigative Dermatology, 1982
- THYMUS DEPENDENT LYMPHOCYTES IN LEPROSY .1. LYMPHOCYTE-T SUB-POPULATIONS DEFINED BY MONOCLONAL-ANTIBODIES1982
- IMBALANCES IN T-CELL SUB-POPULATIONS IN LEPROMATOUS LEPROSY1982
- DEFECT IN THE GENERATION OF CYTO-TOXIC T-CELLS IN LEPROMATOUS LEPROSY1982
- STUDIES ON T-CELL SUBSETS AND FUNCTIONS IN LEPROSY1981
- Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineageProceedings of the National Academy of Sciences, 1980
- VARIATIONS IN DINITROCHLOROBENZENE RESPONSIVITY IN UNTREATED LEPROSY - EVIDENCE OF A BENEFICIAL ROLE FOR ANERGY1980
- Lepromin-Induced Suppressor Cells in Patients with LeprosyThe Journal of Immunology, 1979