Lipid Peroxidation in Iron-Overloaded Spleens
- 1 March 1981
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 60 (3) , 295-301
- https://doi.org/10.1042/cs0600295
Abstract
1. Iron-overloaded spleens from thalassaemic subjects showed a greatly increased susceptibility to free-radical oxidation (peroxidation) in vitro. 2. Iron content was the main but not the only variable governing susceptibility. Added ascorbate had a dose-dependent action either as an antioxidant or as a pro-oxidant, the direction of its effect depending mainly on the degree of iron overload. This has therapeutic implications.Keywords
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