THE PREVENTION BY SULPHYDRYL COMPOUNDS OF THE TOXICITY IN THE CAT OF 2,6‐DIMETHOXYPHENOL AND ITS MORPHOLINOPROPIONYL ESTER

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Abstract
Intravenous (—)‐2,6‐dimethoxyphenyl‐2‐morpholinopropionate hydrochloride (M&B 16,573) produced anaesthesia of short duration in the mouse, rat, rabbit, cat, dog and monkey. In the cat but not in other species, a severe and usually fatal toxic reaction was seen 1‐2 h after administration. This toxic reaction but not the anaesthetic properties of M&B 16,573 was prevented by the intravenous administration of cysteine or N‐acetylcysteine. Cysteamine or dimercaprol were ineffective. Intravenous administration of 2,6‐dimethoxyphenol or 2,6‐dimethoxyquinol in the cat produced a response similar to the delayed toxic effects of M&B 16,573 but not preceded by anaesthesia. The toxic effects of these compounds were prevented by cysteine. Intravenous 4‐allyl‐2,6‐dimethoxyphenyl‐2‐morpholinoprop*ionate hydrochloride produced anaesthesia in the cat without the delayed toxic effects seen after M&B 16,573. The acute toxicity of 2,6‐dimethoxyquinol in mice was reduced by the administration of cysteine or N‐acetylcysteine. It is postulated that the delayed effects produced by M&B 16,573 in the cat are due to the formation of 2,6‐dimethoxyquinol and 2,6‐dimethoxybenzoquinone in this species, the toxicity of the latter being reduced by sulphydryl compounds.

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