Mode of interaction between β-lactam antibiotics and the exocellular DD-carboxypeptidase–transpeptidase from Streptomyces R39.
- 1 June 1976
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 155 (3) , 623-629
- https://doi.org/10.1042/bj1550623
Abstract
The exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39 is inhibited by .beta.-lactam antibiotics according to the same general scheme of reaction as the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61. The values for the kinetic constants involved in the reaction are very different for the 2 enzymes and provide an explanation for the observation that the R39 enzyme is more sensitive to .beta.-lactam antibiotics than the R61 enzyme. Particular .beta.-lactams influence the kinetic constants to different extents depending on the source of the enzyme, so that a physical basis for the spectrum of antibiotic activity against particular enzyme systems is provided.This publication has 13 references indexed in Scilit:
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