EFFECTS OF PARENTERAL AMINOPHYLLINE ON LUNG-MECHANICS IN NORMAL HUMAN

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Abstract
Effects of an i.v. injection of 5.0 mg aminophylline/kg body wt on lung mechanics in 8 normal subjects was studied. No change occurred in lung volumes, airway resistance and maximal expiratory flow-volume and lung pressure-volume curves. Restudy of 4 of the subjects before and after an injection of 8.0 mg/kg aminophylline did not modify the pattern of response to the drug, despite a serum concentration range of 15.1-19.3 mg/l. These findings were in contrast to those observed after administration of atropine or .beta.-2 adrenergic derivatives. Bronchodilator effects of aminophylline may not be due to a direct action of the drug on the bronchial smooth muscle.