STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE QUINOLONE GROUP - ANTI-BACTERIAL ACTIVITY OF 2 NEW COMPOUNDS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. A132  (3) , 267-281
Abstract
Structure-activity relationships in the quinolone group are described. The antibacterial activity of 2 new compounds, pefloxacin and its demethyl derivative, AM-715, were studied. This group of antimicrobial agents were examined for derivatives that are more active, with a broader spectrum, less biotransformed and susceptible to general infections and [human] urinary tract infections.