PET reconstruction with system matrix derived from point source measurements

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Abstract
The quality of images reconstructed by statistical iterative methods depends on an accurate model of the relationship between image space and projection space through the system matrix. A method of acquiring the system matrix on the CPS Innovations the HiRez scanner was developed. The system matrix was derived by positioning the point source in the scanner field of view and processing the response in projection space. Such responses include geometrical and detection physics components of the system matrix. The response is parameterized to correct point source location and to smooth projection noise. Special attention was paid to span concepts of HiRez scanner. The projection operator for iterative reconstruction was constructed, taking into account estimated response parameters. The computer generated and acquired data were used to compare reconstruction obtained by the HiRez standard software and produced by better modeling. Results showed that the better resolution and noise property can be achieved.