Pyocyanine Biosynthesis by Pseudomonas aeruginosa

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Abstract
Pyocyanine is a phenazine derivative with antibiotic activity. A number of factors governing its formation from resting cells were investigated. Glutamic acid and closely related compounds were shown to be good substrates; magnesium ions were essential. Synthesis was inhibited by a number of respiratory poisons. The rate of formation was slow, and efforts to increase it were not successful.