Regulatory functions of protein kinase c in glomerular mesangial cells
- 1 November 1990
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 68 (22) , 1134-1137
- https://doi.org/10.1007/bf01798064
Abstract
Protein kinase C is a family of isozymes that are activated by hormone-stimulated phosphoinositide hydrolysis and participate in the signalling process by phosphorylating certain target proteins. In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade. Furthermore, protein kinase C activates a phosphatidylcholine-degrading phospholipase D activity with as-yet-unknown cellular function.This publication has 28 references indexed in Scilit:
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