Hb-Alberta or α2β2(101(G3) GLU→GLY), a New High-Oxygen-Affinity Hemoglobin Variant Causing Erythrocytosis
- 1 January 1976
- journal article
- case report
- Published by Taylor & Francis in Hemoglobin
- Vol. 1 (2) , 183-194
- https://doi.org/10.3109/03630267608991679
Abstract
Hb-Alberta has been found in a 51 year old Caucasian male with erythrocytosis. The substitution in this variant involves the glutamyl residue in position lOl(G3) of the β chain which is replaced by a glycyl residue. Hb-Alberta accounts for about 45% in the heterozygote, and readily forms hybrid tetramers with other hemoglobins. The oxygen affinity of Hb-Alberta is greatly increased, its Bohr effect reduced, and its subunit interaction greatly diminished.Keywords
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