Lipoproteins, Coronary Heart Disease, and Atherosclerosis

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Abstract
The evidence implicating certain classes of human serum lipoproteins in human coronary heart disease and coronary artery atherosclerosis was reviewed. The role of diastolic hypertension in the development of human coronary heart disease is shown to be, at least in part, independent of the role of serum lipoproteins. A composite function, the alpha function, including information from the lipoprotein and diastolic blood pressure findings, was calculated. This function was utilized in estimating relative risks of development of human coronary heart disease. The time-integrated exposure to alpha-function levels provides predictive information concerning coronary heart disease in reasonable accord with actual experience.