Simultaneous Multivariate Spectrophotometric Analysis of Binary and Ternary Mixtures of Sulfamethoxazole, Trimethoprim and Phenazopyridine in Tablets
- 1 January 1999
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 32 (7) , 1389-1401
- https://doi.org/10.1080/00032719908542905
Abstract
The use of multivariate spectrophotometric calibration is reported for the analysis of tablets containing the antibiotics sulfamethoxazole and trimethoprim, and a combination of the former two drugs with the analgesic phenazopyridine. The resolution of these mixtures has been accomplished without prior separation, derivatisation or use of nonaqueous solvents, with the aid of partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. The analytes have been simultaneously determined with high accuracy and precision, and with no interference from tablet excipients.Keywords
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