Lack of association of hla‐drb1 genotype with radiologic progression in japanese patients with early rheumatoid arthritis

Open Access
Publisher Website
Google Scholar
Abstract
Objective. To evaluate the role of HLA-DRB1 genotypes in the development and progression of the rheumatoid arthritis (RA) disease process. Methods. Patients with polyarthritis of Results. We enrolled 198 patients (median disease duration 5.0 months) and 150 controls. The frequency of individuals with DRB1*0405 and *0410 was significantly higher in the patients than in the controls. Homozygous states for DRB1 alleles with the RArelated shared epitope (SE) were associated with increased susceptibility for the development of polyarthritis (odds ratio 3.4, 95% confidence interval 1.5–7.7). None of the DRB1 alleles or SE genotypes correlated with the presence of bone erosion at presentation or 1 year later. Conclusion. DRB1 alleles with SEs were associated with the development of polyarthritis but not with early radiographic progression of the disease process.