TREATMENT OF NON-HODGKINS LYMPHOMA WITH MARROW TRANSPLANTATION IN IDENTICAL-TWINS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (3) , 509-513
Abstract
Eight patients with disseminated non-Hodgkin''s lymphoma who failed conventional combination chemotherapy were treated with high-dose chemotherapy, a supralethal dose of total-body irradiation and a bone marrow transplant from a normal identical twin. Seven patients experienced complete remissions. Four of the 7 patients (2 with diffuse poorly differentiated lymphocytic lymphoma, 1 with composite lymphoma and 1 with diffuse moderately well differentiated lymphotytic lymphoma) remain in complete unmaintained remission 12-126 mo. from transplantation. One patient relapsed after 10 mo. but was retreated and is alive in unmaintained complete remission 73 mo. from transplantation. One patient died of Pseudomonas pneumonia while in complete remission; 1 patient relapsed and died of progressive lymphoma. Intensive chemoradiotherapy and twin marrow transplantation evidently can induce frequent and enduring remissions in patients with disseminated non-Hodgkin''s lymphoma who have failed conventional therapy.