Intravenously Given Conjugated Estrogens

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Abstract
A double-blind crossover study comparing intravenously administered conjugated estrogens (CE) and a placebo failed to demonstrate a significant effect on capillary resistance to a standard negative pressure stress or the bleeding time in normal subjects. The occurrence of deep calf vein thrombosis within 24 hours of CE administration in a healthy 46-year-old male volunteer raised the possibility of an etiologic relationship. The study did not support the widely held contention that CE promote hemostasis in normal individuals by enhancing capillary stability.

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