Infection, Anergy and Cell-Mediated Immunity

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Abstract
THE purpose of this presentation is to discuss the mechanisms of anergy, defined here as a patient's failure to react to skin tests to which he has previously reacted. Anergy is differentiated from tolerance in that anergy is nonspecific, is usually transient and occurs in the presence of serum antibodies against antigens to which the patient is anergic. Recent experiments with bacterial and viral systems show the ubiquitous association of anergy with infection and hypersensitivity. These experiments suggest that anergy is a normal aspect of the immune response, sometimes so abbreviated as to be undetected, and that clinically detected anergy . . .

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